96 research outputs found
Community-Aware Transformer for Autism Prediction in fMRI Connectome
Autism spectrum disorder(ASD) is a lifelong neurodevelopmental condition that
affects social communication and behavior. Investigating functional magnetic
resonance imaging (fMRI)-based brain functional connectome can aid in the
understanding and diagnosis of ASD, leading to more effective treatments. The
brain is modeled as a network of brain Regions of Interest (ROIs), and ROIs
form communities and knowledge of these communities is crucial for ASD
diagnosis. On the one hand, Transformer-based models have proven to be highly
effective across several tasks, including fMRI connectome analysis to learn
useful representations of ROIs. On the other hand, existing transformer-based
models treat all ROIs equally and overlook the impact of community-specific
associations when learning node embeddings. To fill this gap, we propose a
novel method, Com-BrainTF, a hierarchical local-global transformer architecture
that learns intra and inter-community aware node embeddings for ASD prediction
task. Furthermore, we avoid over-parameterization by sharing the local
transformer parameters for different communities but optimize unique learnable
prompt tokens for each community. Our model outperforms state-of-the-art (SOTA)
architecture on ABIDE dataset and has high interpretability, evident from the
attention module. Our code is available at
https://github.com/ubc-tea/Com-BrainTF.Comment: Accepted by 26th International Conference on Medical Image Computing
and Computer Assisted Intervention (MICCAI 2023
On Fairness of Medical Image Classification with Multiple Sensitive Attributes via Learning Orthogonal Representations
Mitigating the discrimination of machine learning models has gained
increasing attention in medical image analysis. However, rare works focus on
fair treatments for patients with multiple sensitive demographic ones, which is
a crucial yet challenging problem for real-world clinical applications. In this
paper, we propose a novel method for fair representation learning with respect
to multi-sensitive attributes. We pursue the independence between target and
multi-sensitive representations by achieving orthogonality in the
representation space. Concretely, we enforce the column space orthogonality by
keeping target information on the complement of a low-rank sensitive space.
Furthermore, in the row space, we encourage feature dimensions between target
and sensitive representations to be orthogonal. The effectiveness of the
proposed method is demonstrated with extensive experiments on the CheXpert
dataset. To our best knowledge, this is the first work to mitigate unfairness
with respect to multiple sensitive attributes in the field of medical imaging
LESS: Label-efficient Multi-scale Learning for Cytological Whole Slide Image Screening
In computational pathology, multiple instance learning (MIL) is widely used
to circumvent the computational impasse in giga-pixel whole slide image (WSI)
analysis. It usually consists of two stages: patch-level feature extraction and
slide-level aggregation. Recently, pretrained models or self-supervised
learning have been used to extract patch features, but they suffer from low
effectiveness or inefficiency due to overlooking the task-specific supervision
provided by slide labels. Here we propose a weakly-supervised Label-Efficient
WSI Screening method, dubbed LESS, for cytological WSI analysis with only
slide-level labels, which can be effectively applied to small datasets. First,
we suggest using variational positive-unlabeled (VPU) learning to uncover
hidden labels of both benign and malignant patches. We provide appropriate
supervision by using slide-level labels to improve the learning of patch-level
features. Next, we take into account the sparse and random arrangement of cells
in cytological WSIs. To address this, we propose a strategy to crop patches at
multiple scales and utilize a cross-attention vision transformer (CrossViT) to
combine information from different scales for WSI classification. The
combination of our two steps achieves task-alignment, improving effectiveness
and efficiency. We validate the proposed label-efficient method on a urine
cytology WSI dataset encompassing 130 samples (13,000 patches) and FNAC 2019
dataset with 212 samples (21,200 patches). The experiment shows that the
proposed LESS reaches 84.79%, 85.43%, 91.79% and 78.30% on a urine cytology WSI
dataset, and 96.88%, 96.86%, 98.95%, 97.06% on FNAC 2019 dataset in terms of
accuracy, AUC, sensitivity and specificity. It outperforms state-of-the-art MIL
methods on pathology WSIs and realizes automatic cytological WSI cancer
screening.Comment: This paper was submitted to Medical Image Analysis. It is under
revie
Design, fabrication, and cold test of a high frequency system for an H-band sheet beam travelling wave tube
The design, fabrication and cold test of a high frequency system (HFS) for an H-band (220-325GHz) sheet beam travelling wave tube is presented in this article. The HFS was composed of a 90-period double-staggered grating waveguide and a pair of identical L-shaped couplers with Bragg reflectors and matching steps. The HFS was manufactured by nano-computer numerical control machining and its electromagnetic properties were measured by using a vector network analyzer. The measured S-parameters were in good agreement with the simulated ones, which predicted a 3 dB bandwidth of âŒ47.0 GHz. The maximum value of the measured transmission coefficient S 21 was -4.9 dB and the in-band port reflection S 11 was around -15.0 dB. Based on the cold testing-based HFS, simulations of the beam wave interaction predicted a stable output power of over 55.1 W in the frequency range of 230-280 GHz. In addition, the instabilities of the beam wave interaction were investigated in the simulation
Instructive Feature Enhancement for Dichotomous Medical Image Segmentation
Deep neural networks have been widely applied in dichotomous medical image
segmentation (DMIS) of many anatomical structures in several modalities,
achieving promising performance. However, existing networks tend to struggle
with task-specific, heavy and complex designs to improve accuracy. They made
little instructions to which feature channels would be more beneficial for
segmentation, and that may be why the performance and universality of these
segmentation models are hindered. In this study, we propose an instructive
feature enhancement approach, namely IFE, to adaptively select feature channels
with rich texture cues and strong discriminability to enhance raw features
based on local curvature or global information entropy criteria. Being
plug-and-play and applicable for diverse DMIS tasks, IFE encourages the model
to focus on texture-rich features which are especially important for the
ambiguous and challenging boundary identification, simultaneously achieving
simplicity, universality, and certain interpretability. To evaluate the
proposed IFE, we constructed the first large-scale DMIS dataset Cosmos55k,
which contains 55,023 images from 7 modalities and 26 anatomical structures.
Extensive experiments show that IFE can improve the performance of classic
segmentation networks across different anatomies and modalities with only
slight modifications. Code is available at https://github.com/yezi-66/IFEComment: Accepted by MICCAI 202
Strong Electronic Interaction of Amorphous Fe2O3 Nanosheets with SingleâAtom Pt toward Enhanced Carbon Monoxide Oxidation
Platinumâbased catalysts are critical to several chemical processes, but their efficiency is not satisfying enough in some cases, because only the surface activeâsite atoms participate in the reaction. Henceforth, catalysts with singleâatom dispersions are highly desirable to maximize their mass efficiency, but fabricating these structures using a controllable method is still challenging. Most previous studies have focused on crystalline materials. However, amorphous materials may have enhanced performance due to their distorted and isotropic nature with numerous defects. Here reported is the facile synthesis of an atomically dispersed catalyst that consists of single Pt atoms and amorphous Fe2O3 nanosheets. Rational control can regulate the morphology from single atom clusters to subânanoparticles. Density functional theory calculations show the synergistic effect resulted from the strong binding and stabilization of single Pt atoms with the strong metalâsupport interaction between the in situ locally anchored Pt atoms and Fe2O3 lead to a weak CO adsorption. Moreover, the distorted amorphous Fe2O3 with O vacancies is beneficial for the activation of O2, which further facilitates CO oxidation on nearby Pt sites or interface sites between Pt and Fe2O3, resulting in the extremely high performance for CO oxidation of the atomic catalyst.An atomically Pt dispersed catalyst on amorphous Fe2O3 nanosheets is developed. The size effect of Pt and phase effect of support are explored. The synergistic effect results from the strong metalâsupport interactions between the single Pt atoms and the amorphous Fe2O3 structure supports lead to an enhanced CO oxidation performance.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/151833/1/adfm201904278-sup-0001-S1.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151833/2/adfm201904278.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151833/3/adfm201904278_am.pd
Boosting Oxygen and Peroxide Reduction Reactions on PdCu Intermetallic Cubes
Palladiumâbased nanocatalysts have the potential to replace platinumâbased catalysts for fuelâcell reactions in alkaline electrolytes, especially PdCu intermetallic nanoparticles with high electrochemical activity and stability. However, unlike the synthetic methods for obtaining the nanoparticles, the effect of PdCu shape on the performance is relatively less well studied. Here, we demonstrate the facet dependence of PdCu intermetallics on the oxygen reduction reaction (ORR) and peroxide reduction, and reveal that the {100} dominant PdCu cubes have a much higher ORR mass activity and specific activity than spheres at 0.9â
V vs. RHE, which is four and five times that of commercial Pd/C and Pt/C catalysts, respectively, and show only a 31.7â% decay after 30â000â
cycles in the stability test. Moreover, cubic PdCu nanoparticles show higher peroxide electroreduction activity than Pd cubes and PdCu spheres. Density functional theory (DFT) calculation reveals that the huge difference originates from the reduction in oxygen adsorption energy and energy barrier of peroxide decomposition on the ordered {100} PdCu surface. Given the relationship between the shape and electrochemical performance, this study will contribute to further research on electrocatalytic improvements of catalysts in alkaline environments.Shape the future: PdCu intermetallic cubes and spheres are synthesized to investigate the facet dependence on the oxygen reduction reaction and peroxide reduction. The cubes show large improvements in mass activity towards both reactions, compared with the spheres. DFT calculation uncovers that the dominant {100} faces of the cubes offer more appropriate oxygen adsorption and are thermodynamically favorable for peroxide reduction compared to the surface of spheres.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155903/1/celc202000381.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155903/2/celc202000381_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155903/3/celc202000381-sup-0001-misc_information.pd
A NonâPt Electronically Coupled Semiconductor Heterojunction for Enhanced Oxygen Reduction Electrocatalytic Property
Hybrid facetedâAg3PO4/cubeâCu2O composite materials have been fabricated and employed as oxygen reduction electrocatalysts for proton exchange membrane fuel cells (PEMFCs). The charge separation effect via the formation of PN junction has been demonstrated to boost the electrocatalysis toward oxygen reduction reaction. The asâprepared rhombic dodecahedronâAg3PO4/cubeâCu2O/C hybrid catalyst shows a massâspecific activity of 109.80â
mA/mgAg, which is about 6.4 times that of pure rhombic dodecahedronâAg3PO4/C catalyst (17.20â
mA/mgAg). The density functional theory (DFT) calculation based on the density of states (DOS) further proved the optimal tunable effect, which is in pace with demonstration of electron transfer direction revealed by Xâray photoelectron spectroscopy (XPS) analysis. Our work establishes a theoretical and practical basis for the rational design of newly nonâPt hybrid catalysts, moreover, advances the future efficient application of PEMFCs.A cost effective electronically coupled semiconductor heterojunction between facetâAg3PO4 and Cu2O cube is reported. Its high electrocatalytic activity towards oxygen reduction reaction (ORR) indicates that electron distribution can be controlled through the interfacial engineering between Ag3PO4 and Cu2O. This paves way to rationally design new nonâPt hybrid catalysts, and moreover advances the future efficient applications of proton exchange membrane fuel cells (PEMFCs).Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149290/1/slct201900615.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149290/2/slct201900615-sup-0001-misc_information.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149290/3/slct201900615_am.pd
Titanium Nitride Film on Sapphire Substrate with Low Dielectric Loss for Superconducting Qubits
Dielectric loss is one of the major decoherence sources of superconducting
qubits. Contemporary high-coherence superconducting qubits are formed by
material systems mostly consisting of superconducting films on substrate with
low dielectric loss, where the loss mainly originates from the surfaces and
interfaces. Among the multiple candidates for material systems, a combination
of titanium nitride (TiN) film and sapphire substrate has good potential
because of its chemical stability against oxidization, and high quality at
interfaces. In this work, we report a TiN film deposited onto sapphire
substrate achieving low dielectric loss at the material interface. Through the
systematic characterizations of a series of transmon qubits fabricated with
identical batches of TiN base layers, but different geometries of qubit
shunting capacitors with various participation ratios of the material
interface, we quantitatively extract the loss tangent value at the
substrate-metal interface smaller than in 1-nm disordered
layer. By optimizing the interface participation ratio of the transmon qubit,
we reproducibly achieve qubit lifetimes of up to 300 s and quality factors
approaching 8 million. We demonstrate that TiN film on sapphire substrate is an
ideal material system for high-coherence superconducting qubits. Our analyses
further suggest that the interface dielectric loss around the Josephson
junction part of the circuit could be the dominant limitation of lifetimes for
state-of-the-art transmon qubits
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